pISSN 2234-7518
eISSN 2005-372X

Level of evidence according to the AMSTAR 2 assessment tool

Level Description
High No or one non-critical weakness: the systematic review provides an accurate and comprehensive summary of the results of the available studies that address the question of interest.
Moderate More than one non-critical weakness*: the systematic review has more than one weakness but no critical flaws. It may provide an accurate summary of the results of the available studies that were included in the review.
Low One critical flaw with or without non-critical weaknesses: the review has a critical flaw and may not provide an accurate and comprehensive summary of the available studies that address the question of interest.
Critically low More than one critical flaw with or without non-critical weaknesses: the review has more than one critical flaw and should not be relied on to provide an accurate and comprehensive summary of the available studies.

AMSTAR 2, A Measurement Tool to Assess Systematic Reviews.

*Multiple non-critical weaknesses may diminish the confidence in the review, and it may be appropriate to move the overall appraisal down from moderate to low confidence.

Korean J Orthod 2022;52:220~235 https://doi.org/10.4041/kjod21.153
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