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Korean J Orthod 2020; 50(4): 227-228

Published online July 25, 2020 https://doi.org/10.4041/kjod.2020.50.4.227

Copyright © The Korean Association of Orthodontists.


Seung-Youp Lee

Department of Orthodontics, School of Dentistry, Jeonbuk National University, Iksan, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Soonshin Hwang, Chooryung J. Chung, Yoon Jeong Choi, Taeyeon Kim, Kyung-Ho Kim

The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion.

- Korean J Orthod 2020;50:42-51

In recent days, environmental pollution has become a big issue to all of us. I agree with the authors about atopic dermatitis and asthma as I see many children under orthodontic care are also treated for the conditions as well. So, I am impressed by your work regarding the effect of histamine 1 receptor antagonists (H1RAs) and also appreciative of your results, which may help rapid maxillary expansion cases.

Q1. How do you expect H1RAs to affect tooth movement based on your study?

Q2. There are many anti-histamine drugs available worldwide. Your choice was cetirizine in this investigation. Could you explain more about the cetirizine and your reasoning behind this selection?

Q3. It seems there had been delayed histological examination results. In the expansion group a significant level of difference was observed at the 28-day observation period. Also, both osteocalcin and carboxy-terminal collagen crosslinks were seen at day 28. Would please comment on those delays, including what it could mean about its clinical application?

Questioned by

Seung-Youp Lee

Department of Orthodontics, School of Dentistry, Jeonbuk National University, Iksan, Korea

We would like to express our appreciation for the interest in our published article.

A1. A previous study by Meh et al.1 applied cetirizine treatment to show differences in tooth movements in a rat model. The same study also showed decreased amount of tooth movement and osteoclast volume density (p < 0.001) from day 28 onward.1 Therefore, it would be reasonable to expect an interference with orthodontic tooth movement after cetirizine administration.

A2. There are two major reasons in using cetirizine in this study. First, H1RAs have been shown to increase the mechanical properties of the bone by inhibiting bone resorption.2 Second, one of the major side effects of antihistamine intake is drowsiness. However, cetirizine shows a low incidence of sedative effects most likely caused by its diminished potential to cross the blood-brain barrier.3 In a clinical setting, a patient suffering from allergic symptoms would be more likely to take antihistamines with less side effects.

A3. Suppression in osteoclastic activity occurred at day 28, which was in line with a previous study by Meh et al.1 From the results of this present study, it is difficult to suspect a definite reason for this delayed effect. However, although this study was in a rat model, the results of this study suggest that an intake of H1RA may aid in stability of the expanded suture area by increased bone formation. This could be a clinically positive effect in terms of stably maintaining expanded craniofacial sutures in orthognathic treatment.

Replied by

Kyung-Ho Kim

Department of Orthodontics, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University, Seoul, Korea

  1. Meh A, Sprogar S, Vaupotic T, Cör A, Drevenšek G, Marc J, et al. Effect of cetirizine, a histamine (H(1)) receptor antagonist, on bone modeling during orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop 2011;139:e323-9.
    Pubmed CrossRef
  2. Dobigny C, Saffar JL. H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model. J Cell Physiol 1997;173:10-8.
  3. Snowman AM, Snyder SH. Cetirizine: actions on neurotransmitter receptors. J Allergy Clin Immunol 1990;86(6 Pt 2):1025-8.
    Pubmed CrossRef