모바일 메뉴

KJO Korean Journal of Orthodontics

Open Access

pISSN 2234-7518
eISSN 2005-372X
QR Code QR Code

퀵메뉴 버튼

Article

home All Articles View
Split Viewer

Article In Press

Korean J Orthod

Published online February 3, 2021

Copyright © The Korean Association of Orthodontists.

Chewing gum as non-pharmacologic alternative for orthodontic pain relief: a randomized clinical trial under an Intention-to-Treat analysis

Diego Junior da Silva Santosa,c,d; Jonas Capelli Jr.b,d

a. PhD Student, Department of Preventive and Community Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
b. Full Professor of Orthodontics, Department of Preventive and Community Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
c. Private practice
d. Brazilian Board of Orthodontics Certificated

Correspondence to:Diego Junior da Silva Santos
Address: Avenida Ataulfo de Paiva, 1460, apt 601, Leblon, Rio de Janeiro-RJ, Brazil
CEP: 22440-035
Phone: +55 (21) 98027-2082; e-mail: diegorsdrj@gmail.com.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives: To compare the effectiveness of ibuprofen, acetaminophen, and chewing gum for orthodontic pain relief and to assess if chewing gum can be a nonpharmacologic alternative for orthodontics pain relief. Methods: 106 patients were enrolled. The eligibility criteria were age ≥12 years, body mass >50 kg, either sex, mild-to-moderate dental crowding in the upper arch. After randomization and allocation concealment, intervention groups were administered ibuprofen 400 mg, acetaminophen 500 mg, or chewed sugar-free chewing gum immediately after initial archwire placement and every six h, for one week, if the pain persisted. The control group did not receive any pain relief. The outcome was the assessment of pain experience on 100 mm visual analog scales (VAS) at time intervals of T1-2, T2-24 h, and T3- 2 days, T4- 3 days, T5- days 7, and T6- 21 days, at rest, and during bite hard. Statistical analyses were performed using Kruskal-Wallis repeated measures and Mann-Whitney U post-hoc signed-rank tests (α=0.05). Results: chewing gum group experienced more pain relief than ibuprofen at T3- rest and during bite (P ≤ 0.05) and at T4 - rest (P < 0.001). Chewing gum group, during bite, reported more pain relief than acetaminophen (P= 0.03) and control (P= ≤ .001) at T3, and than acetaminophen (P= 0.02) and control (P= ≤ .001) at T3. Conclusions: Chewing gum can be a non-pharmacologic alternative for orthodontic pain relief at 2 and 3 days after initial archwire placement.

Keywords: pain, ibuprofen, acetaminophen, randomized clinical trial

Article

ahead

Korean J Orthod

Published online February 3, 2021

Copyright © The Korean Association of Orthodontists.

Chewing gum as non-pharmacologic alternative for orthodontic pain relief: a randomized clinical trial under an Intention-to-Treat analysis

Diego Junior da Silva Santosa,c,d; Jonas Capelli Jr.b,d

a. PhD Student, Department of Preventive and Community Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
b. Full Professor of Orthodontics, Department of Preventive and Community Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
c. Private practice
d. Brazilian Board of Orthodontics Certificated

Correspondence to:Diego Junior da Silva Santos
Address: Avenida Ataulfo de Paiva, 1460, apt 601, Leblon, Rio de Janeiro-RJ, Brazil
CEP: 22440-035
Phone: +55 (21) 98027-2082; e-mail: diegorsdrj@gmail.com.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives: To compare the effectiveness of ibuprofen, acetaminophen, and chewing gum for orthodontic pain relief and to assess if chewing gum can be a nonpharmacologic alternative for orthodontics pain relief. Methods: 106 patients were enrolled. The eligibility criteria were age ≥12 years, body mass >50 kg, either sex, mild-to-moderate dental crowding in the upper arch. After randomization and allocation concealment, intervention groups were administered ibuprofen 400 mg, acetaminophen 500 mg, or chewed sugar-free chewing gum immediately after initial archwire placement and every six h, for one week, if the pain persisted. The control group did not receive any pain relief. The outcome was the assessment of pain experience on 100 mm visual analog scales (VAS) at time intervals of T1-2, T2-24 h, and T3- 2 days, T4- 3 days, T5- days 7, and T6- 21 days, at rest, and during bite hard. Statistical analyses were performed using Kruskal-Wallis repeated measures and Mann-Whitney U post-hoc signed-rank tests (α=0.05). Results: chewing gum group experienced more pain relief than ibuprofen at T3- rest and during bite (P ≤ 0.05) and at T4 - rest (P < 0.001). Chewing gum group, during bite, reported more pain relief than acetaminophen (P= 0.03) and control (P= ≤ .001) at T3, and than acetaminophen (P= 0.02) and control (P= ≤ .001) at T3. Conclusions: Chewing gum can be a non-pharmacologic alternative for orthodontic pain relief at 2 and 3 days after initial archwire placement.

Keywords: pain, ibuprofen, acetaminophen, randomized clinical trial