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KJO Korean Journal of Orthodontics

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pISSN 2234-7518
eISSN 2005-372X
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Korean J Orthod   

First Published Date August 23, 2022

Copyright © The Korean Association of Orthodontists.

Enhancement of bioactivity and osseointegration to Ti-6Al-4V orthodontic mini-screws coated with calcium phosphate on the TiO2 nanotube layer

Seon-Mi Byeona; Hye-Ji Kimb; Min-Ho Leec; Tae-Sung Baed

a Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea
b Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea
c Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea
d Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea

Correspondence to:Tae-Sung Bae, Professor, Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, South Korea 54896, Tel: + 82 0632704041; Fax: +82 0632704040; E-mail: bts@jbnu.ac.kr

Abstract

Objective: This study evaluated the effect of cyclic pre-calcification treatment on the improvement of bioactivity and osseointegration of Ti-6Al-4V mini-screws. Methods: The experimental groups were divided into three groups, namely the untreated group (UT), the anodized and heat-treated group (AH), and the anodized treatment followed by the cyclic pre-calcification treatment group (ASPH). A bioactive material with calcium phosphate was coated on the mini-screws, and its effects on bioactivity and osseointegration were evaluated by in vitro and in vivo tests of the mini-screws implanted in the rat tibia. Results: As a result of immersing the ASPH group in SBF for 2 days, protrusions appearing in the initial stage of hydroxyapatite precipitation were observed, and on the 3rd day, the protrusions became more densified, and growth occurred in the thickness direction, and Ca and P concentrations increased. The removal torque values significantly increased from UT (2.08 ± 0.67 N·cm) to AH (4.10 ± 0.72 N·cm) and ASPH (6.58 ± 0.66 N·cm) groups, and the ASPH group showed the highest value (p < 0.05). The ASPH group observed that a new bone was connected to the threads, and it was confirmed that a bony bridge connected to the adjacent bone was formed. Conclusions: In conclusion, it was found that the surface treatment method of the ASPH group improved the bioactivity and osseointegration of Ti-6Al-4V orthodontic mini-screws.

Keywords: Biocompatibility, Cyclic pre-calcification, Orthodontic mini-implant, Osseointegration

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Korean J Orthod   

First Published Date August 23, 2022

Copyright © The Korean Association of Orthodontists.

Enhancement of bioactivity and osseointegration to Ti-6Al-4V orthodontic mini-screws coated with calcium phosphate on the TiO2 nanotube layer

Seon-Mi Byeona; Hye-Ji Kimb; Min-Ho Leec; Tae-Sung Baed

a Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea
b Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea
c Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea
d Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si, South Korea

Correspondence to:Tae-Sung Bae, Professor, Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, 567, Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, South Korea 54896, Tel: + 82 0632704041; Fax: +82 0632704040; E-mail: bts@jbnu.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: This study evaluated the effect of cyclic pre-calcification treatment on the improvement of bioactivity and osseointegration of Ti-6Al-4V mini-screws. Methods: The experimental groups were divided into three groups, namely the untreated group (UT), the anodized and heat-treated group (AH), and the anodized treatment followed by the cyclic pre-calcification treatment group (ASPH). A bioactive material with calcium phosphate was coated on the mini-screws, and its effects on bioactivity and osseointegration were evaluated by in vitro and in vivo tests of the mini-screws implanted in the rat tibia. Results: As a result of immersing the ASPH group in SBF for 2 days, protrusions appearing in the initial stage of hydroxyapatite precipitation were observed, and on the 3rd day, the protrusions became more densified, and growth occurred in the thickness direction, and Ca and P concentrations increased. The removal torque values significantly increased from UT (2.08 ± 0.67 N·cm) to AH (4.10 ± 0.72 N·cm) and ASPH (6.58 ± 0.66 N·cm) groups, and the ASPH group showed the highest value (p < 0.05). The ASPH group observed that a new bone was connected to the threads, and it was confirmed that a bony bridge connected to the adjacent bone was formed. Conclusions: In conclusion, it was found that the surface treatment method of the ASPH group improved the bioactivity and osseointegration of Ti-6Al-4V orthodontic mini-screws.

Keywords: Biocompatibility, Cyclic pre-calcification, Orthodontic mini-implant, Osseointegration