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Korean J Orthod
First Published Date September 22, 2023
Copyright © The Korean Association of Orthodontists.
Martina Ferrillo,1* 
Dario Calafiore,2 Lorenzo Lippi,3,4 Francesco Agostini,5,6 Mario Migliario,7 Marco Invernizzi,3,4 Amerigo Giudice,1 Alessandro de Sire8
1Dentistry Unit, Department of Health Sciences, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, Italy
2Physical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, Italy
3Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont “A. Avogadro”, 28100 Novara, Italy
4Translational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
5Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy
6Department of Neurological and Rehabilitation Science, IRCCS San Raffaele, 00163 Rome, Italy
7Dentistry Unit, Department of Translational Medicine, University of Eastern Piedmont “A. Avogadro”, 28100 Novara, Italy
8Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, Italy
Correspondence to:Dr. Martina Ferrillo, DDS
Dentistry Unit, Department of Health Sciences University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy
Phone: +390961712819; Email: martina.ferrillo@unicz.it
https://orcid.org/0000-0003-1878-4694
Objectives: This systematic review aimed to evaluate the state-of-art on the correlation between vitamin D and rate of tooth movement, external apical root resorption, bone biomarkers expression, and bone remodeling.
Materials and methods: Three databases (PubMed, Scopus, and Web of Science) were systematically searched from inception until 14th March 2023 to identify studies investigating the correlation between orthodontic tooth movement and vitamin D in both animals and humans. The quality assessment was made in accordance with the Joanna Briggs Institute Critical Appraisal Checklist.
Results: Overall, 519 records were identified and 19 were selected for the qualitative synthesis. Eleven studies investigated the effect of local administration (injections in the periodontal ligament, or to the gingiva distal to the teeth, or submucosae palatal area) and systemic administration (oral supplementation) of vitamin D on tooth movement, external apical root movement, pro-inflammatory cytokines, and bone remodeling factors. The remaining 8 studies investigated the correlation between serum vitamin D levels and salivary vitamin D levels on bone turnover markers and tooth movement.
Conclusions: Taking together, findings of this systematic review supported that vitamin D3 local injections might increase the rate of tooth movement via RANK/OPG axis. However, the non-uniform study designs and the different protocol and outcome methods make it difficult to draw reliable conclusions.
Keywords: Vitamin D, Calcitriol, Orthodontic tooth movement, External apical root resorption.
Korean J Orthod
First Published Date September 22, 2023
Copyright © The Korean Association of Orthodontists.
Martina Ferrillo,1* Dario Calafiore,2 Lorenzo Lippi,3,4 Francesco Agostini,5,6 Mario Migliario,7 Marco Invernizzi,3,4 Amerigo Giudice,1 Alessandro de Sire8
1Dentistry Unit, Department of Health Sciences, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, Italy
2Physical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, Italy
3Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont “A. Avogadro”, 28100 Novara, Italy
4Translational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
5Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy
6Department of Neurological and Rehabilitation Science, IRCCS San Raffaele, 00163 Rome, Italy
7Dentistry Unit, Department of Translational Medicine, University of Eastern Piedmont “A. Avogadro”, 28100 Novara, Italy
8Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, Italy
Correspondence to:Dr. Martina Ferrillo, DDS
Dentistry Unit, Department of Health Sciences University of Catanzaro "Magna Graecia", Viale Europa, 88100 Catanzaro, Italy
Phone: +390961712819; Email: martina.ferrillo@unicz.it
https://orcid.org/0000-0003-1878-4694
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objectives: This systematic review aimed to evaluate the state-of-art on the correlation between vitamin D and rate of tooth movement, external apical root resorption, bone biomarkers expression, and bone remodeling.
Materials and methods: Three databases (PubMed, Scopus, and Web of Science) were systematically searched from inception until 14th March 2023 to identify studies investigating the correlation between orthodontic tooth movement and vitamin D in both animals and humans. The quality assessment was made in accordance with the Joanna Briggs Institute Critical Appraisal Checklist.
Results: Overall, 519 records were identified and 19 were selected for the qualitative synthesis. Eleven studies investigated the effect of local administration (injections in the periodontal ligament, or to the gingiva distal to the teeth, or submucosae palatal area) and systemic administration (oral supplementation) of vitamin D on tooth movement, external apical root movement, pro-inflammatory cytokines, and bone remodeling factors. The remaining 8 studies investigated the correlation between serum vitamin D levels and salivary vitamin D levels on bone turnover markers and tooth movement.
Conclusions: Taking together, findings of this systematic review supported that vitamin D3 local injections might increase the rate of tooth movement via RANK/OPG axis. However, the non-uniform study designs and the different protocol and outcome methods make it difficult to draw reliable conclusions.
Keywords: Vitamin D, Calcitriol, Orthodontic tooth movement, External apical root resorption.
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