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Korean J Orthod
Copyright © The Korean Association of Orthodontists.
1. Mustafa UZUN (first author and corresponding author)
2. Mine GEÇGELEN CESUR
3. Ömer ERDOĞAN
Mustafa UZUN: Aydın Adnan Menderes University, Faculty of Dentistry, Department of Orthodontics (Orthodontist, mustafa.uzunn0@gmail.com, +90 533 833 19 27)
Mine GEÇGELEN CESUR: Aydın Adnan Menderes University, Faculty of Dentistry, Department of Orthodontics (Associate Professor, minegecgelen@hotmail.com, +90 544 749 01 99)
Ömer ERDOĞAN: Gaziantep İslam Bilim ve Teknoloji University, Faculty of Medicine, Department of Medical Biochemistry (Assistant Professor, omer.erdogan@gibtu.edu.tr, +90 541 270 60 27)
Objective: This study aims to evaluate bone remodeling in gingival crevicular fluid during canine distalization in obese individuals and to compare it to normal weight individuals. Additionally, obese individuals’ orthodontic tooth movement rates be measured and compared to normal weight individuals.
Methods: Thirty-six patients (18 obese and 18 normal weight) aged 12 to 18, who were candidates for maxillary first premolar extraction treatment for Angle Class II malocclusion were included in the study. Two groups were formed according to WHO. A normal weight group (BMI 16-85%) and an obese group (BMI ≥95%). GCF samples were taken before, 24 hours after, and on the 7th, 14th and 21st days of the application of distalization force. ELISA method was used to measure Leptin, RANKL, OPG and IL-6 levels from the GCF samples. In addition to recorded GCF sampling times, the amount of canine tooth movement was calculated with digital models obtained on the 28th day and the 3rd month.
Results: Leptin, RANKL, OPG and IL-6 levels are statistically significantly higher in the obese group (p<0.05). Digital model measurements display high rates of repeatability (ICC-0.990). Difference in amount of tooth movement between the groups is not statistically significant (p>0.05).
Conclusion: Though obese and normal weight individuals showed different biomarker levels during tooth movement, there was no difference in the amounts of movement.
Keywords: Leptin, Biomarker, Obesity, Orthodontic tooth movement
Korean J Orthod
First Published Date August 29, 2024
Copyright © The Korean Association of Orthodontists.
1. Mustafa UZUN (first author and corresponding author)
2. Mine GEÇGELEN CESUR
3. Ömer ERDOĞAN
Mustafa UZUN: Aydın Adnan Menderes University, Faculty of Dentistry, Department of Orthodontics (Orthodontist, mustafa.uzunn0@gmail.com, +90 533 833 19 27)
Mine GEÇGELEN CESUR: Aydın Adnan Menderes University, Faculty of Dentistry, Department of Orthodontics (Associate Professor, minegecgelen@hotmail.com, +90 544 749 01 99)
Ömer ERDOĞAN: Gaziantep İslam Bilim ve Teknoloji University, Faculty of Medicine, Department of Medical Biochemistry (Assistant Professor, omer.erdogan@gibtu.edu.tr, +90 541 270 60 27)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: This study aims to evaluate bone remodeling in gingival crevicular fluid during canine distalization in obese individuals and to compare it to normal weight individuals. Additionally, obese individuals’ orthodontic tooth movement rates be measured and compared to normal weight individuals.
Methods: Thirty-six patients (18 obese and 18 normal weight) aged 12 to 18, who were candidates for maxillary first premolar extraction treatment for Angle Class II malocclusion were included in the study. Two groups were formed according to WHO. A normal weight group (BMI 16-85%) and an obese group (BMI ≥95%). GCF samples were taken before, 24 hours after, and on the 7th, 14th and 21st days of the application of distalization force. ELISA method was used to measure Leptin, RANKL, OPG and IL-6 levels from the GCF samples. In addition to recorded GCF sampling times, the amount of canine tooth movement was calculated with digital models obtained on the 28th day and the 3rd month.
Results: Leptin, RANKL, OPG and IL-6 levels are statistically significantly higher in the obese group (p<0.05). Digital model measurements display high rates of repeatability (ICC-0.990). Difference in amount of tooth movement between the groups is not statistically significant (p>0.05).
Conclusion: Though obese and normal weight individuals showed different biomarker levels during tooth movement, there was no difference in the amounts of movement.
Keywords: Leptin, Biomarker, Obesity, Orthodontic tooth movement
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