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Korean J Orthod
Copyright © The Korean Association of Orthodontists.
Viviane Oliveira Prado1, DDS, MD, PhD student
Maria Eugenia Queiroz Nassur2, MD, PhD, Professor
Israel D Souza2, PhD student
Paulo Nelson-Filho1, DDS, MD, PhD, Professor
Karla Carpio Horta3, DDS, MD, PhD, Professor
Fabio Lourenço Romano1, DDS, MD, PhD, Professor
Ana Paula Valladares de Almeida1, DDS, MD student
Caio Luiz Bitencourt Reis1, DDS, MD, PhD student
Maria Bernadete Sasso Stuani1, DDS, MD, PhD, Professor
Mirian Aiko Nakane Matsumoto1*, DDS, MD, PhD, Professor
1 – Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil
2 – Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Brazil
3 - Edmonton Clinic Health Academy, Faculty of Medicine and Dentistry, University of Alberta, Canada
Correspondence to:Caio Luiz Bitencourt Reis
School of Dentistry of Ribeirão Preto, University of São Paulo Av. do Café, s/n, Monte Alegre, Ribeirão Preto, São Paulo 14040-904, Brazil
caioluizreis@usp.br
Objective: Over the years, literature has increasingly highlighted the toxic potential of Bisphenol A (BPA), particularly in children, even at low doses. This study aimed to evaluate the BPA release in the saliva of children with Haas expanders. Methods: Twenty-five children of both sexes 6 to 10 years old who needed rapid maxillary expansion were recruited. After one week, with permanent molars separated with an elastic, the patients returned to adapt orthodontic bands and obtain the maxillary impressions with alginate. The Haas expander was fabricated in plaster models with a standardized amount of acrylic resin. The bands were cemented with the Transbond Plus Light Cure Band (3M). Saliva samples were collected in five time points: before (T0), and 30 minutes (T1), 1 hour (T2), 24 hours (T3), 1 week (T4), and 1 month (T5) after the Haas expander installation. BPA level measurements were performed by Ultra-high performance liquid chromatography coupled with Tandem Mass Spectrometry, and results were statistically evaluated through ANOVA and Tukey's post-hoc test, with a significance level of 5%. Results: The BPA release was below the recommended Tolerable Daily Intake (TDI), but the amount of BPA released in saliva at T1 (70.2 ng/mL-1 ± 37.05) was significantly higher compared to T0 (0.47 ng/mL-1 ± 0.27) (p<0.05), indicating increased levels of BPA in children's organisms. Conclusions: There was a significant BPA increase in saliva, after the first 30 minutes following the installation of Haas expander.
Keywords: Expansion, Adhesive, Appliances, Biocompatibility
Korean J Orthod
First Published Date December 24, 2024
Copyright © The Korean Association of Orthodontists.
Viviane Oliveira Prado1, DDS, MD, PhD student
Maria Eugenia Queiroz Nassur2, MD, PhD, Professor
Israel D Souza2, PhD student
Paulo Nelson-Filho1, DDS, MD, PhD, Professor
Karla Carpio Horta3, DDS, MD, PhD, Professor
Fabio Lourenço Romano1, DDS, MD, PhD, Professor
Ana Paula Valladares de Almeida1, DDS, MD student
Caio Luiz Bitencourt Reis1, DDS, MD, PhD student
Maria Bernadete Sasso Stuani1, DDS, MD, PhD, Professor
Mirian Aiko Nakane Matsumoto1*, DDS, MD, PhD, Professor
1 – Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil
2 – Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Brazil
3 - Edmonton Clinic Health Academy, Faculty of Medicine and Dentistry, University of Alberta, Canada
Correspondence to:Caio Luiz Bitencourt Reis
School of Dentistry of Ribeirão Preto, University of São Paulo Av. do Café, s/n, Monte Alegre, Ribeirão Preto, São Paulo 14040-904, Brazil
caioluizreis@usp.br
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: Over the years, literature has increasingly highlighted the toxic potential of Bisphenol A (BPA), particularly in children, even at low doses. This study aimed to evaluate the BPA release in the saliva of children with Haas expanders. Methods: Twenty-five children of both sexes 6 to 10 years old who needed rapid maxillary expansion were recruited. After one week, with permanent molars separated with an elastic, the patients returned to adapt orthodontic bands and obtain the maxillary impressions with alginate. The Haas expander was fabricated in plaster models with a standardized amount of acrylic resin. The bands were cemented with the Transbond Plus Light Cure Band (3M). Saliva samples were collected in five time points: before (T0), and 30 minutes (T1), 1 hour (T2), 24 hours (T3), 1 week (T4), and 1 month (T5) after the Haas expander installation. BPA level measurements were performed by Ultra-high performance liquid chromatography coupled with Tandem Mass Spectrometry, and results were statistically evaluated through ANOVA and Tukey's post-hoc test, with a significance level of 5%. Results: The BPA release was below the recommended Tolerable Daily Intake (TDI), but the amount of BPA released in saliva at T1 (70.2 ng/mL-1 ± 37.05) was significantly higher compared to T0 (0.47 ng/mL-1 ± 0.27) (p<0.05), indicating increased levels of BPA in children's organisms. Conclusions: There was a significant BPA increase in saliva, after the first 30 minutes following the installation of Haas expander.
Keywords: Expansion, Adhesive, Appliances, Biocompatibility
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