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KJO Korean Journal of Orthodontics

Open Access

pISSN 2234-7518
eISSN 2005-372X

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Korean J Orthod   

Copyright © The Korean Association of Orthodontists.

Correlation between Prevotella intermedia and intraoral metal alloys

M. Florinda Oteroa,b, Raquel Dos-Santosc, Eva Pérez-Pampínc, Antonio Merac, Jorge Mirad,*

a Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
b Private Practice, Santiago de Compostela, Spain.
c Hospital Clínico Universitario and Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
d Departamento de Física Aplicada and Instituto de Materiais (iMATUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Correspondence to:Jorge Mira
Professor, Departamento de Física Aplicada, Facultade de Física Universidade de Santiago de Compostela E-15782 Santiago de Compostela, Spain
Email: jorge.mira@usc.es
Phone: +34 881814028

Accepted: March 9, 2025

Abstract

We investigate a possible association of oral metal alloys with the presence of Prevotella intermedia in a group with rheumatoid arthritis (RA). Bacteriological tests in a case-control study were performed. Cases were 80 patients with RA (40 of them positive in Prevotella intermedia and 40 negatives in it). Controls were 81 subjects without RA (39 positive in Prevotella intermedia and 42 negatives in it). Univariate analysis identifies the presence of oral metal alloys (lingual fix retainers or metal/ceramic crown), male sex and the presence of gingival inflammation as predictors of the appearance of Prevotella Intermedia (P<.05). In multivariate analysis the presence of intraoral metal alloys was the strongest association with an OR=4.21 (P<.001). No difference in positivity of Prevotella intermedia is observed between groups. Then, intraoral metal alloys are related with the increase of Prevotella intermedia in subgingival pockets in adult population, independently of RA.

Keywords: Oral bacteria, prevotella intermedia, dysbiosis, oral metal alloys, rheumatoid arthritis.

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Korean J Orthod   

First Published Date March 12, 2025

Copyright © The Korean Association of Orthodontists.

Correlation between Prevotella intermedia and intraoral metal alloys

M. Florinda Oteroa,b, Raquel Dos-Santosc, Eva Pérez-Pampínc, Antonio Merac, Jorge Mirad,*

a Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
b Private Practice, Santiago de Compostela, Spain.
c Hospital Clínico Universitario and Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
d Departamento de Física Aplicada and Instituto de Materiais (iMATUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Correspondence to:Jorge Mira
Professor, Departamento de Física Aplicada, Facultade de Física Universidade de Santiago de Compostela E-15782 Santiago de Compostela, Spain
Email: jorge.mira@usc.es
Phone: +34 881814028

Accepted: March 9, 2025

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigate a possible association of oral metal alloys with the presence of Prevotella intermedia in a group with rheumatoid arthritis (RA). Bacteriological tests in a case-control study were performed. Cases were 80 patients with RA (40 of them positive in Prevotella intermedia and 40 negatives in it). Controls were 81 subjects without RA (39 positive in Prevotella intermedia and 42 negatives in it). Univariate analysis identifies the presence of oral metal alloys (lingual fix retainers or metal/ceramic crown), male sex and the presence of gingival inflammation as predictors of the appearance of Prevotella Intermedia (P<.05). In multivariate analysis the presence of intraoral metal alloys was the strongest association with an OR=4.21 (P<.001). No difference in positivity of Prevotella intermedia is observed between groups. Then, intraoral metal alloys are related with the increase of Prevotella intermedia in subgingival pockets in adult population, independently of RA.

Keywords: Oral bacteria, prevotella intermedia, dysbiosis, oral metal alloys, rheumatoid arthritis.